Increased risk of GI effects in elderly, patients w/ history of GI disease eg, ulceration & GI bleeding, concomitant use w/ other NSAID or ASA. Risk of thrombotic events, eg, MI or stroke. Periodically re-evaluate need for symptomatic relief & response to therapy. Should consider carefully before treatment patients w/ significant risk factors for CV events (eg, HTN, hyperlipidaemia, DM, smoking). Preexisting impaired renal function, uncompensated heart failure or cirrhosis. Monitor renal & liver function. History of cardiac failure, left ventricular dysfunction, HTN & those w/ preexisting oedema. Control HTN prior to treatment; monitor BP w/in 2 wk after initiation of treatment & periodically thereafter. Discontinue if signs of hepatic insufficiency or if persistently abnormal LFTs (>3x ULN); deterioration of any organ system functions; skin rash, mucosal lesions or any other sign of hypersensitivity occurs. Patients w/ dehydration; rehydrate patients prior to starting treatment. May mask fever & other signs of inflammation. Concomitant use w/ warfarin or other oral anticoagulants. May affect ability to drive or operate machinery. Women attempting to conceive.